November 13, 2023. The Use of Allopurinol to Reduce the Serum Uric Acid in Patients with Hyperuricemia and CKD can delay Progression of CKD

Article name: Use of Allopurinol in Slowing the Progression of Renal Disease Through Its Ability to Lower Serum Uric Acid Level

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DOI

This article was published in the American Journal of Kidney Diseases in 2006. It is a a prospective, randomized, controlled trial of 54 hyperuricemic patients with chronic kidney disease. The patients were assigned to a treatment with allopurinol arm and a treatment as usual arm,

Allopurinol did reduce the uric acid level significantly from 9.75 ± 1.18 mg/dL (0.58 ± 0.07 mmol/L) to 5.88 ± 1.01 mg/dL (0.35 ± 0.06 mmol/L; P < 0.001). In 12 months, 4 of 25 patients (16%) in the allopurinol arm reached the combined end points of significant progression in renal function compared with 12 of 26 patients (46.1%) in the control group (P = 0.015)

Allopurinol may reduce the progression of CKD in patients with CKD with hyperuricemia

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